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In page R. J. Reynolds Tobacco Company:

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By 1953, RJ Reynolds held an internal belief that cigarettes caused cancer. On February 2nd of that year, RJ Reynolds research chemist and executive Claude Teague released 'Survey of Cancer Research', a confidential internal document for RJ Reynolds upper management.[1] He concluded that clinical data was confirming the fact that tobacco was "an important etiologic factor in the induction of primary cancer of the lung." He also wrote that many findings of animal studies "would seem to indicate the presence of carcinogens."[2]