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In page Setter:

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They are fast, stylish game-finding dogs with a unique history and evolution for the single purpose of finding game birds.[2] Writing in 1576 Dr Johannes Caius states "There is also at this date among us a new kind of dogge brought out of Fraunce, and they bee speckled all over with white and black, which mingled colours incline to a marble blewe". Argue speculates this may be a description of the blue belton colour found in English setters.[2]