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In page Alagille syndrome:

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Several medications are used to improve bile flow, including Ursodiol (Actigall or Urso).[1] These medications differ in their rates of success. Certain drugs may be used to reduce itching (pruritus), such as cholestyramine and rifampin. While these medications can reduce pruritus, the itching often is reduced when bile flow is improved via Ursodiol or liver transplant.[1]