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In page Gelfand representation:

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One of the most significant applications is the existence of a continuous functional calculus for normal elements in C*-algebra A: An element x is normal if and only if x commutes with its adjoint x*, or equivalently if and only if it generates a commutative C*-algebra C*(x). By the Gelfand isomorphism applied to C*(x) this is *-isomorphic to an algebra of continuous functions on a locally compact space. This observation leads almost immediately to: