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"*Myelocortical multiple sclerosis (MCMS), proposed variant with demyelination of spinal cord and cerebral cortex but not of cerebral white matter [1] Several atypical cases could belong here. See the early reports of MCMS<[2][3] *Opticospinal MS or Optic-spinal MS (OSMS): Old OSMS cases are now considered inside the NMO spectrum, but this does not apply to anti-AQP4 negative cases.[4] After the discovery of anti-AQP4 autoantibodies it was found that some cases of OSMS were AQP4-negative, and therefore, they are considered real MS cases. OSMS has its own specific immunological biomarkers[5] The whole picture is under construction and several reports exists about overlapping conditions.
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