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In page House of Guise:

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The House of Guise was founded as a cadet branch of the House of Lorraine by Claude of Lorraine, first Duke of Guise (1496–1550), who entered French service and was made a duke by King Francis I. The family's high rank was due not to possession of the Guise dukedom but to their membership in a sovereign dynasty, which procured for them the rank of prince étranger at the royal court of France. Claude's daughter Mary of Guise (1515–1560) married King James V of Scotland and was mother of Mary, Queen of Scots. Claude's eldest son, Francis, became a military hero thanks to his heroic defense of Metz in 1552, and the capture of Calais from the English in 1558, while another son, Charles became Archbishop of Reims and a Cardinal in the Catholic Church.