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In page CASS4:
"In a genome wide association screen (GWAS), CASS4 showed a significant correlation with clinical pathological features of AD such as neurofibrillary tangles and neuritic plaques.[4] Two additional CASS4 SNPs were reported to be associated with AD susceptibility: rs6024870,[5] and rs16979934 T/G.[6] Given the likely conserved CAS-family cytoskeletal function of CASS4, it has been speculated that it may have a role in axonal transport and influence the expression of the amyloid precursor protein (APP) and tau, which are pathologically affected in AD.[7] Several possible mechanisms for CASS4 action in AD have been proposed.[8]
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