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In page Molecular oncology:
"There is room for improvement with this gene therapy approach. Firstly, the antigens of interest expressed on the cancer cells may sometimes be expressed on regular body cells, too.[1] This means the body's T cells will attack its own healthy cells instead of the cancer cells when the antigen is lacking specificity with just the cancer cell.[1] A possible solution to this problem is to include two different antigen receptors on the CAR-T cells to make them even more specific.[1] The second issue with the CAR-T immunotherapy approach is that it can cause cytokine release syndrome. This is when an excess of pro-inflammatory factors are released by the immune system and can cause unpleasant side effects for the patient like nausea and a high fever.[1]
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