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In page Flight surgeon:

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The roots of aviation medicine extend back to the earliest scientific discoveries of gas laws and the makeup of earth's atmosphere as these factors relate to the human body. As aviation progressed from lighter-than-air balloons to fixed wing controlled flight to spaceflight, the disciplines of medicine and physiology were required to track with each technological advance. Physicians and physiologists, such as John Jeffries (1745-1819) and Paul Bert (1833-1886), conducted experiments on humans in flight and documented the body's response to these physiologic stressors.[1] However, it would not be until airplanes were first used in war that the office of the first flight surgeon was established.