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In page HEPA:

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HEPA filtration works by mechanical means unlike the ionic and ozone filtration which use negative ions and ozone gas respectively. So, the chances of potential pulmonary side-effects like asthma[1] and allergies is much lower with HEPA purifiers.[2] To ensure that a HEPA filter is working efficiently, they should be checked and changed at least every six months in commercial settings. In residential settings, they can be changed every two to three years. Failing to change a HEPA filter in a timely fashion will result in it putting stress on the machine or system and not removing particles from the air properly.[3]