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In page Goitrogen:
"*Ions such as thiocyanate[6] (from cigarette smoking for example[7]) and perchlorate decrease iodide uptake by competitive inhibition and, as a consequence of reduced thyroxine and triiodothyronine secretion by the gland, cause, at low doses, an increased release of thyrotropin (by reduced negative feedback), which then stimulates the gland.
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