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In page Arthur M. Sackler:

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In the early 1940s he joined medical advertising agency William Douglas McAdams Inc.,[1] where he remained active until his death.[2] Sackler transformed the agency with sales techniques hitherto unknown to pharmaceutical manufacturers. A Harvard University historian wrote in 2019 that the Sacklers did not invent direct sales to physicians but they were a pioneering influence. Arthur Sackler marketed in publications targeting physicians directly which increased the pace at which doctors learned about medicines and brought them to market, but did not ever participate in sales force canvasing and detailing, a technique now under tremendous scrutiny.[3]