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In page Ciclosporin:

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Ciclosporin also binds to the cyclophilin D protein that constitutes part of the mitochondrial permeability transition pore (MPTP).[3][6] The MPTP is found in the mitochondrial membrane of cardiac muscle cells and moves calcium ions (Ca2+
) into the mitochondria.[3][6] When open, Ca2+
enters the mitochondria and causes the muscle cells (and thus the heart) to contract.
If unregulated, the influx of Ca2+ can contribute to mitochondrial swelling and dysfunction.[6]