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In page Hairy cell leukemia:
"In June 2011, E Tiacci et al[3][4] discovered that 100% of hairy-cell leukaemia samples analysed had the oncogenic BRAF mutation V600E, and proposed that this is the disease's driver mutation. Until this point, only a few genomic imbalances had been found in the hairy cells, such as trisomy 5 had been found.[1] The expression of genes is also dysregulated in a complex and specific pattern. The cells under express 3p24, 3p21, 3q13.3-q22, 4p16, 11q23, 14q22-q24, 15q21-q22, 15q24-q25, and 17q22-q24 and overexpress 13q31 and Xq13.3-q21.[5] It has not yet been demonstrated that any of these changes have any practical significance to the patient.
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