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In page Sodium thiopental:

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Thiopental (Pentothal) is still used in some places as a truth serum to weaken the resolve of a subject and make them more compliant to pressure.[1] The barbiturates as a class decrease higher cortical brain functioning, and also due to the loss of inhibition produced by barbiturates. Some psychiatrists[who?] hypothesize that because lying is more complex than telling the truth, suppression of the higher cortical functions may lead to the uncovering of the truth. The drug tends to make subjects loquacious and cooperative with interrogators; however, the reliability of confessions made under thiopental is questionable.[2]