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In page Ciclosporin:
"Ciclosporin is highly metabolized in humans and animals after ingestion. The metabolites, which include cyclosporin B, C, D, E, H, and L,[2] have less than 10% of ciclosporin's immunosuppressant activity and are associated with higher kidney toxicity.[3] Individual ciclosporin metabolites have been isolated and characterized but do not appear to be extensively studied.
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