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In page Inverse problem:
"Also the user may wish to add physical constraints to the models : in this case they have to be familiar with constrained optimization methods, a subject in itself. In all cases, computing the gradient of the objective function often is a key element for the solution of the optimization problem. As mentioned above, information about the spatial distribution of a distributed parameter can be introduced through the parametrization. One can also think of adapting this parametrization during the optimization.[3]
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