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In page Spectrin:
"Some evidence for the role of spectrins in muscle tissues exist. In myocardial cells, aII spectrin distribution is coincident with Z-discs and the plasma membrane of myofibrils.[1] Additionally, mice with an ankyrin (ankB) knock-out have disrupted calcium homeostasis in the myocardia. Affected mice have disrupted z-band and sarcomere morphology. In this experimental model ryanodine and IP3 receptors have abnormal distribution in cultured myocytes. The calcium signaling of the cultured cells is disrupted. In humans, a mutation within the AnkB gene results in the long QT syndrome and sudden death, strengthening the evidence for a role for the spectrin cytoskeleton in excitable tissue.
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